Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling A Nakao, M Afrakhte, A Morn, T Nakayama, JL Christian, R Heuchel, ... Nature 389 (6651), 631-635, 1997 | 2415 | 1997 |
The transcription factor MTF‐1 is essential for basal and heavy metal‐induced metallothionein gene expression. R Heuchel, F Radtke, O Georgiev, G Stark, M Aguet, W Schaffner The EMBO journal 13 (12), 2870-2875, 1994 | 607 | 1994 |
Cloned transcription factor MTF‐1 activates the mouse metallothionein I promoter. F Radtke, R Heuchel, O Georgiev, M Hergersberg, M Gariglio, Z Dembic, ... The EMBO journal 12 (4), 1355-1362, 1993 | 467 | 1993 |
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy E Lonardo, PC Hermann, MT Mueller, S Huber, A Balic, ... Cell stem cell 9 (5), 433-446, 2011 | 454 | 2011 |
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing P Longati, X Jia, J Eimer, A Wagman, MR Witt, S Rehnmark, C Verbeke, ... BMC cancer 13, 1-13, 2013 | 426 | 2013 |
Embryonic lethality and liver degeneration in mice lacking the metal‐responsive transcriptional activator MTF‐1 Ç Günes, R Heuchel, O Georgiev, KH Müller, P Lichtlen, H Blüthmann, ... The EMBO journal, 1998 | 338 | 1998 |
Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl J Zeng, R Heuchel, W Schaffner, JHR Kägi FEBS letters 279 (2), 310-312, 1991 | 333 | 1991 |
Transforming growth factor-β1 (TGF-β)–induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-β-activated kinase 1 and mitogen-activated … S Edlund, S Bu, N Schuster, P Aspenstrom, R Heuchel, NE Heldin, ... Molecular biology of the cell 14 (2), 529-544, 2003 | 327 | 2003 |
The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential HY Chen, XR Huang, W Wang, JH Li, RL Heuchel, ACK Chung, HY Lan Diabetes 60 (2), 590-601, 2011 | 272 | 2011 |
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate M Furuhashi, T Sjöblom, A Abramsson, J Ellingsen, P Micke, H Li, ... Cancer research 64 (8), 2725-2733, 2004 | 264 | 2004 |
Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1 E Brugnera, O Georgiev, F Radtke, R Heuchel, E Baker, GR Sutherland, ... Nucleic acids research 22 (15), 3167-3173, 1994 | 257 | 1994 |
Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling R Heuchel, A Berg, M Tallquist, K Åhlén, RK Reed, K Rubin, ... Proceedings of the National Academy of Sciences 96 (20), 11410-11415, 1999 | 234 | 1999 |
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice ACK Chung, XR Huang, L Zhou, R Heuchel, KN Lai, HY Lan Nephrology Dialysis Transplantation 24 (5), 1443-1454, 2009 | 212 | 2009 |
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer E Hessmann, MS Patzak, L Klein, N Chen, V Kari, I Ramu, TE Bapiro, ... Gut 67 (3), 497-507, 2018 | 211 | 2018 |
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin … V Pant, P Mariano, C Kanduri, A Mattsson, V Lobanenkov, R Heuchel, ... Genes & development 17 (5), 586-590, 2003 | 208 | 2003 |
Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter G Brodin, A Åhgren, P ten Dijke, CH Heldin, R Heuchel Journal of Biological Chemistry 275 (37), 29023-29030, 2000 | 198 | 2000 |
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation M Arsura, GR Panta, JD Bilyeu, LG Cavin, MA Sovak, AA Oliver, V Factor, ... Oncogene 22 (3), 412-425, 2003 | 194 | 2003 |
Desmoplasia and chemoresistance in pancreatic cancer M Schober, R Jesenofsky, R Faissner, C Weidenauer, W Hagmann, ... Cancers 6 (4), 2137-2154, 2014 | 175 | 2014 |
Profibrogenic transforming growth factor‐β/activin receptor–like kinase 5 signaling via connective tissue growth factor expression in hepatocytes HL Weng, L Ciuclan, Y Liu, J Hamzavi, P Godoy, H Gaitantzi, S Kanzler, ... Hepatology 46 (4), 1257-1270, 2007 | 153 | 2007 |
Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound M Gerling, Y Zhao, S Nania, KJ Norberg, CS Verbeke, B Englert, ... Theranostics 4 (6), 604, 2014 | 137 | 2014 |