Articles with public access mandates - Martin LepsikLearn more
Not available anywhere: 7
Assessing the accuracy and performance of implicit solvent models for drug molecules: conformational ensemble approaches
M Kolar, J Fanfrlik, M Lepsik, F Forti, FJ Luque, P Hobza
The Journal of Physical Chemistry B 117 (19), 5950-5962, 2013
Mandates: Government of Spain
The effect of halogen-to-hydrogen bond substitution on human aldose reductase inhibition
J Fanfrlik, FX Ruiz, A Kadlcikova, J Rezac, A Cousido-Siah, A Mitschler, ...
ACS chemical biology 10 (7), 1637-1642, 2015
Mandates: National Institute of Health and Medical Research, France
Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy
P Srb, M Svoboda, L Benda, M Lepšík, J Tarábek, V Šícha, B Grüner, ...
Physical Chemistry Chemical Physics 21 (10), 5661-5673, 2019
Mandates: European Commission
Nonclassical Hydrophobic Effect in Micellization: Molecular Arrangement of Non‐Amphiphilic Structures
M Uchman, AI Abrikosov, M Lepšík, M Lund, P Matějíček
Advanced Theory and Simulations 1 (1), 1700002, 2018
Mandates: Swedish Research Council
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo
N Dayal, E Reznickova, DE Hernandez, M Perina, S Torregrosa-Allen, ...
Journal of Medicinal Chemistry 64 (15), 10981-10996, 2021
Mandates: US National Science Foundation, US National Institutes of Health, Helmholtz …
Targeting the insulin receptor with hormone and peptide dimers
J Lin, I Selicharová, K Mitrová, B Fabre, VM Miriyala, M Lepšík, J Jiráček, ...
Journal of Peptide Science 29 (4), e3461, 2023
Mandates: UK Medical Research Council
Synthesis of a series of novel homo-and hetero-glycoclusters and their binding activities to DC-SIGN.
X Cai, G Fu, M Lepšik, E Paci, Y Guo, Z Li, Q Li
Journal of Chinese Pharmaceutical Sciences 30 (11), 2021
Mandates: National Natural Science Foundation of China, Wellcome Trust
Available somewhere: 20
Metallacarboranes and their interactions: theoretical insights and their applicability
P Farras, EJ Juarez-Perez, M Lepšík, R Luque, R Nunez, F Teixidor
Chemical Society Reviews 41 (9), 3445-3463, 2012
Mandates: Government of Spain
Modulation of aldose reductase inhibition by halogen bond tuning
J Fanfrlik, M Kolar, M Kamlar, D Hurny, FX Ruiz, A Cousido-Siah, ...
ACS Chemical Biology 8 (11), 2484-2492, 2013
Mandates: National Institute of Health and Medical Research, France
Structural integrity of the B24 site in human insulin is important for hormone functionality
L Žáková, E Kletvíková, V Veverka, M Lepšík, CJ Watson, JP Turkenburg, ...
Journal of Biological Chemistry 288 (15), 10230-10240, 2013
Mandates: UK Biotechnology and Biological Sciences Research Council, UK Medical …
General and modular strategy for designing potent, selective, and pharmacologically compliant inhibitors of rhomboid proteases
A Tichá, S Stanchev, KR Vinothkumar, DC Mikles, P Pachl, J Began, ...
Cell chemical biology 24 (12), 1523-1536. e4, 2017
Mandates: US National Institutes of Health, German Research Foundation, UK Medical …
Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex
L Žáková, E Kletvíková, M Lepšík, M Collinsová, CJ Watson, ...
Acta Crystallographica Section D: Biological Crystallography 70 (10), 2765-2774, 2014
Mandates: UK Medical Research Council
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
S Sharma, K Čermáková, J De Rijck, J Demeulemeester, M Fábry, ...
Proceedings of the National Academy of Sciences 115 (30), E7053-E7062, 2018
Mandates: US National Institutes of Health, Research Foundation (Flanders)
Powerful avidity with a limited valency for virus-attachment blockers on DC-SIGN: combining chelation and statistical rebinding with structural plasticity of the receptor
V Porkolab, M Lepsik, S Ordanini, A St John, A Le Roy, M Thépaut, E Paci, ...
ACS Central Science 9 (4), 709-718, 2023
Mandates: European Commission, Agence Nationale de la Recherche
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor-and hormone-specific responses
K Macháčková, K Mlčochová, P Potalitsyn, K Hanková, O Socha, ...
Journal of Biological Chemistry 294 (46), 17371-17382, 2019
Mandates: UK Medical Research Council, UK Research & Innovation
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate
E Zahorska, S Kuhaudomlarp, S Minervini, S Yousaf, M Lepsik, ...
Chemical Communications 56 (62), 8822-8825, 2020
Mandates: German Research Foundation, European Commission, Agence Nationale de la …
In vitro evolution reveals noncationic protein–RNA interaction mediated by metal ions
VG Giacobelli, K Fujishima, M Lepšík, V Tretyachenko, T Kadavá, ...
Molecular biology and evolution 39 (3), msac032, 2022
Mandates: European Commission, Human Frontier Science Program
A γ-cyclodextrin duplex connected with two disulfide bonds: synthesis, structure and inclusion complexes
S Volkov, L Kumprecht, M Buděšínský, M Lepšík, M Dušek, T Kraus
Organic & Biomolecular Chemistry 13 (10), 2980-2985, 2015
Mandates: European Commission
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity
A Jílková, M Horn, J Fanfrlik, J Küppers, P Pachl, P Řezáčová, ...
ACS Infectious Diseases 7 (1), 189-201, 2020
Mandates: Bill & Melinda Gates Foundation, US National Institutes of Health, Helmholtz …
Druggable hot spots in the schistosomiasis cathepsin B1 target identified by functional and binding mode analysis of potent vinyl sulfone inhibitors
A Jílková, P Rubešová, J Fanfrlík, P Fajtová, P Řezáčová, J Brynda, ...
ACS Infectious Diseases 7 (5), 1077-1088, 2020
Mandates: Bill & Melinda Gates Foundation, US National Institutes of Health, Helmholtz …
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