The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b MP Müller, H Peters, J Blümer, W Blankenfeldt, RS Goody, A Itzen Science 329 (5994), 946-949, 2010 | 447 | 2010 |
Molecular control of Rab activity by GEFs, GAPs and GDI MP Müller, RS Goody Small GTPases 9 (1-2), 5-21, 2018 | 227 | 2018 |
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins PR Goody, K Heller, LK Oesterlin, MP Müller, A Itzen, RS Goody The EMBO journal 31 (7), 1774-1784, 2012 | 135 | 2012 |
Bacterial pathogens commandeer Rab GTPases to establish intracellular niches MP Stein, MP Müller, A Wandinger‐Ness Traffic 13 (12), 1565-1588, 2012 | 106 | 2012 |
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer J Weisner, I Landel, C Reintjes, N Uhlenbrock, M Trajkovic-Arsic, ... Cancer research 79 (9), 2367-2378, 2019 | 83 | 2019 |
Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport RS Goody, MP Müller, YW Wu Biological chemistry 398 (5-6), 565-575, 2017 | 83 | 2017 |
KRasG12C inhibitors in clinical trials: a short historical perspective L Goebel, MP Müller, RS Goody, D Rauh RSC medicinal chemistry 11 (7), 760-770, 2020 | 79 | 2020 |
Proximity‐triggered covalent stabilization of low‐affinity protein complexes in vitro and in vivo M Cigler, TG Müller, D Horn‐Ghetko, MK von Wrisberg, M Fottner, ... Angewandte Chemie international edition 56 (49), 15737-15741, 2017 | 73* | 2017 |
2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: Limitations and pitfalls of the photoswitchable inhibitor approach M Schehr, C Lanes, J Weisner, L Heintze, MP Müller, C Pichlo, J Charl, ... Photochemical & Photobiological Sciences 18, 1398-1407, 2019 | 65 | 2019 |
bMERB domains are bivalent Rab8 family effectors evolved by gene duplication A Rai, A Oprisko, J Campos, Y Fu, T Friese, A Itzen, RS Goody, ... Elife 5, e18675, 2016 | 59 | 2016 |
Covalent‐allosteric inhibitors to achieve Akt isoform‐selectivity L Quambusch, I Landel, L Depta, J Weisner, N Uhlenbrock, MP Müller, ... Angewandte Chemie International Edition 58 (52), 18823-18829, 2019 | 54 | 2019 |
Structural and Chemical Insights into the Covalent-allosteric Inhibition of the Protein Kinase Akt N Uhlenbrock, S Smith, J Weisner, I Landel, M Lindemann, TA Le, ... Chemical Science, 2019 | 54 | 2019 |
Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity MP Müller, S Jeganathan, A Heidrich, J Campos, RS Goody Scientific reports 7 (1), 1-11, 2017 | 42 | 2017 |
Augmented Reality in Scientific Publications—Taking the Visualization of 3D Structures to the Next Level P Wolle, MP Müller, D Rauh ACS Chemical Biology 13 (3), 496–499, 2018 | 39 | 2018 |
Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein MP Müller, AV Shkumatov, LK Oesterlin, S Schoebel, PR Goody, ... Journal of Biological Chemistry 287 (42), 35036-35046, 2012 | 37 | 2012 |
Complex crystal structures of EGFR with third-generation kinase inhibitors and simultaneously bound allosteric ligands J Niggenaber, L Heyden, T Grabe, MP Müller, J Lategahn, D Rauh ACS Medicinal Chemistry Letters 11 (12), 2484-2490, 2020 | 35 | 2020 |
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S J Lategahn, M Keul, P Klövekorn, HL Tumbrink, J Niggenaber, MP Müller, ... Chemical Science 10 (46), 10789-10801, 2019 | 35 | 2019 |
Efficient synthesis and applications of peptides containing adenylylated tyrosine residues C Smit, J Blümer, MF Eerland, MF Albers, MP Müller, RS Goody, A Itzen, ... Angewandte Chemie International Edition 39 (50), 9200-9204, 2011 | 31 | 2011 |
Locking GTPases covalently in their functional states D Wiegandt, S Vieweg, F Hofmann, D Koch, F Li, YW Wu, A Itzen, ... Nature communications 6 (1), 7773, 2015 | 29 | 2015 |
Cellular model system to dissect the isoform-selectivity of Akt inhibitors L Quambusch, L Depta, I Landel, M Lubeck, T Kirschner, J Nabert, ... Nature Communications 12 (1), 5297, 2021 | 25 | 2021 |