Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis ML Loh, S Vattikuti, S Schubbert, MG Reynolds, E Carlson, KH Lieuw, ... Blood 103 (6), 2325-2331, 2004 | 501 | 2004 |
Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease M Tartaglia, S Martinelli, L Stella, G Bocchinfuso, E Flex, V Cordeddu, ... The American Journal of Human Genetics 78 (2), 279-290, 2006 | 435 | 2006 |
Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors PD Emanuel, LJ Bates, RP Castleberry, RJ Gualtieri, KS Zuckerman | 407 | 1991 |
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia ML Loh, DS Sakai, C Flotho, M Kang, M Fliegauf, S Archambeault, ... Blood, The Journal of the American Society of Hematology 114 (9), 1859-1863, 2009 | 349 | 2009 |
Transplantation of umbilical cord blood after myeloablative therapy: analysis of engraftment [see comments] JE Wagner, HE Broxmeyer, RL Byrd, B Zehnbauer, B Schmeckpeper, ... | 315 | 1992 |
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease CP Kratz, CM Niemeyer, RP Castleberry, M Cetin, E Bergsträsser, ... Blood 106 (6), 2183-2185, 2005 | 302 | 2005 |
The genomic landscape of juvenile myelomonocytic leukemia E Stieglitz, AN Taylor-Weiner, TY Chang, LC Gelston, YD Wang, T Mazor, ... Nature genetics 47 (11), 1326-1333, 2015 | 285 | 2015 |
Mutations of the NF1 Gene in Children With Juvenile Myelomonocytic Leukemia Without Clinical Evidence of Neurofibromatosis, Type 1 LE Side, PD Emanuel, B Taylor, J Franklin, P Thompson, RP Castleberry, ... Blood, The Journal of the American Society of Hematology 92 (1), 267-272, 1998 | 238 | 1998 |
A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia JP Radich, KJ Kopecky, FR Appelbaum, S Kamel-Reid, W Stock, ... Blood, The Journal of the American Society of Hematology 120 (19), 3898-3905, 2012 | 214 | 2012 |
Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells LS Metelitsa, KI Weinberg, PD Emanuel, RC Seeger Leukemia 17 (6), 1068-1077, 2003 | 197 | 2003 |
Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia PD Emanuel Leukemia 22 (7), 1335-1342, 2008 | 161 | 2008 |
The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation Z Meng, PH King, LB Nabors, NL Jackson, CY Chen, PD Emanuel, ... Nucleic acids research 33 (9), 2962-2979, 2005 | 153 | 2005 |
A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia RP Castleberry, PD Emanuel, KS Zuckerman, S Cohn, L Strauss, RL Byrd, ... New England Journal of Medicine 331 (25), 1680-1684, 1994 | 123 | 1994 |
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia E Stieglitz, CB Troup, LC Gelston, J Haliburton, ED Chow, KB Yu, ... Blood, The Journal of the American Society of Hematology 125 (3), 516-524, 2015 | 98 | 2015 |
Myelodysplasia and myeloproliferative disorders in childhood: an update. PD Emanuel British journal of haematology 105 (4), 1999 | 98 | 1999 |
Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy PD Emanuel, KM Shannon, RP Castleberry Molecular Medicine Today 2 (11), 468-475, 1996 | 94 | 1996 |
Proteasome‐associated autoinflammatory syndromes: advances in pathogeneses, clinical presentations, diagnosis, and management A McDermott, J Jacks, M Kessler, PD Emanuel, L Gao International journal of dermatology 54 (2), 121-129, 2015 | 93 | 2015 |
Juvenile myelomonocytic leukemia. PD Emanuel Current hematology reports 3 (3), 203-209, 2004 | 91 | 2004 |
Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies K Stephens, M Weaver, KA Leppig, K Maruyama, PD Emanuel, ... Blood 108 (5), 1684-1689, 2006 | 88 | 2006 |
Valproic acid-induced cytopenias: evidence for a dose-related suppression of hematopoiesis RG Watts, PD Emanuel, KS Zuckerman, TH Howard The Journal of Pediatrics 117 (3), 495-499, 1990 | 87 | 1990 |