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Michael C Gregory
Michael C Gregory
Verified email at merck.com
Title
Cited by
Cited by
Year
Unveiling the crucial intermediates in androgen production
PJ Mak, MC Gregory, IG Denisov, SG Sligar, JR Kincaid
Proceedings of the National Academy of Sciences 112 (52), 15856-15861, 2015
812015
Nanodiscs: a controlled bilayer surface for the study of membrane proteins
MA McLean, MC Gregory, SG Sligar
Annual review of biophysics 47 (1), 107-124, 2018
782018
Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry
M Gregory, PJ Mak, SG Sligar, JR Kincaid
Angewandte Chemie (International ed. in English) 52 (20), 5342, 2013
782013
Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate
MC Gregory, IG Denisov, YV Grinkova, Y Khatri, SG Sligar
Journal of the American Chemical Society 135 (44), 16245-16247, 2013
772013
Active site proton delivery and the lyase activity of human CYP17A1
Y Khatri, MC Gregory, YV Grinkova, IG Denisov, SG Sligar
Biochemical and biophysical research communications 443 (1), 179-184, 2014
682014
Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes
A Luthra, M Gregory, YV Grinkova, IG Denisov, SG Sligar
Cytochrome P450 Protocols, 115-127, 2013
672013
Interaction of KRas4b with anionic membranes: A special role for PIP2
MC Gregory, MA McLean, SG Sligar
Biochemical and biophysical research communications 487 (2), 351-355, 2017
532017
Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis
R Duggal, Y Liu, MC Gregory, IG Denisov, JR Kincaid, SG Sligar
Biochemical and biophysical research communications 477 (2), 202-208, 2016
432016
Human cytochrome CYP17A1: The structural basis for compromised lyase activity with 17-hydroxyprogesterone
PJ Mak, R Duggal, IG Denisov, MC Gregory, SG Sligar, JR Kincaid
Journal of the American Chemical Society 140 (23), 7324-7331, 2018
422018
Influence of transmembrane helix mutations on cytochrome P450-membrane interactions and function
G Mustafa, PP Nandekar, TJ Camp, NJ Bruce, MC Gregory, SG Sligar, ...
Biophysical journal 116 (3), 419-432, 2019
352019
Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17
PJ Mak, MC Gregory, SG Sligar, JR Kincaid
Biochemistry 53 (1), 90-100, 2014
272014
Human P450 CYP17A1: Control of substrate preference by asparagine 202
MC Gregory, PJ Mak, Y Khatri, JR Kincaid, SG Sligar
Biochemistry 57 (5), 764-771, 2018
102018
Importance of asparagine 202 in manipulating active site structure and substrate preference for human CYP17A1
Y Liu, I Denisov, M Gregory, SG Sligar, JR Kincaid
Biochemistry 61 (7), 583-594, 2022
62022
Mechanism of the clinically relevant E305G mutation in human P450 CYP17A1
Y Liu, Y Grinkova, MC Gregory, IG Denisov, JR Kincaid, SG Sligar
Biochemistry 60 (43), 3262-3271, 2021
62021
Understanding the mechanism of androgen biosynthesis
MC Gregory
University of Illinois at Urbana-Champaign, 2016
22016
Understanding the Role of Anionic Lipids in the Interaction of KRas4b with the Membrane Surface
MA McLean, MC Gregory, T Camp, SG Sligar
Biophysical Journal 116 (3), 298a, 2019
2019
Mehanisms in Cancer Signaling: The Role of the Membrane in the Recruitment of the Oncogene KRas4b
SG Sligar, MC Gregory, MA McLean
Biophysical Journal 114 (3), 32a, 2018
2018
Mechanism and Modulation of Human Androgen Synthesis
R Duggal, MC Gregory, Y Liu, PJ Mak, IG Denisov, JR Kincaid, SG Sligar
The FASEB Journal 31, 920.1-920.1, 2017
2017
Anti-TGF beta receptor II antibody abrogates FoxP3+/TGF\# 946; RII+ Treg cells and enhances antitumor immunity against tumor growth and metastasis
K Carroll, Z Zhong, D Policarpio, M Gregory, R Bassi, X Jimenez, ...
CANCER RESEARCH 69, 2009
2009
Abstract# 844: Anti-TGF beta receptor II antibody suppresses tumor growth and metastasis through inhibiting TGF beta autocrine stimulation of tumor cells and myeloid cells
Z Zhong, D Policarpio, K Carroll, M Gregory, R Bassi, M Prewette, S Wang, ...
Cancer Research 69 (9_Supplement), 844-844, 2009
2009
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Articles 1–20