Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies Y Yamazaki, N Zhao, TR Caulfield, CC Liu, G Bu Nature Reviews Neurology 15 (9), 501-518, 2019 | 1043 | 2019 |
Blood-brain barrier dysfunction and the pathogenesis of Alzheimer’s disease Y Yamazaki, T Kanekiyo International journal of molecular sciences 18 (9), 1965, 2017 | 384 | 2017 |
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 236 | 2020 |
Vascular cell senescence contributes to blood–brain barrier breakdown Y Yamazaki, DJ Baker, M Tachibana, CC Liu, JM van Deursen, TG Brott, ... Stroke, STROKEAHA. 115.010835, 2016 | 226 | 2016 |
Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 186 | 2020 |
ABCA7 deficiency accelerates amyloid-β generation and Alzheimer's neuronal pathology N Sakae, CC Liu, M Shinohara, J Frisch-Daiello, L Ma, Y Yamazaki, ... Journal of Neuroscience 36 (13), 3848-3859, 2016 | 166 | 2016 |
Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression Y Yamazaki, M Shinohara, M Shinohara, A Yamazaki, ME Murray, ... Brain 142 (4), 1077-1092, 2019 | 158 | 2019 |
Apolipoprotein E as a therapeutic target in Alzheimer’s disease: a review of basic research and clinical evidence Y Yamazaki, MM Painter, G Bu, T Kanekiyo CNS drugs 30 (9), 773-789, 2016 | 138 | 2016 |
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1 M Tachibana, ML Holm, CC Liu, M Shinohara, T Aikawa, H Oue, ... The Journal of clinical investigation 129 (3), 1272-1277, 2019 | 137 | 2019 |
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease M Shinohara, ME Murray, RD Frank, M Shinohara, M DeTure, Y Yamazaki, ... Acta neuropathologica 132, 225-234, 2016 | 110 | 2016 |
Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease L Zhang, S Zhang, I Maezawa, S Trushin, P Minhas, M Pinto, LW Jin, ... EBioMedicine 2 (4), 294-305, 2015 | 100 | 2015 |
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, ... Nature neuroscience 25 (8), 1020-1033, 2022 | 97 | 2022 |
Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice M Tachibana, Y Yamazaki, CC Liu, G Bu, T Kanekiyo Experimental neurology 300, 13-21, 2018 | 71 | 2018 |
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway CS Casey, Y Atagi, Y Yamazaki, M Shinohara, M Tachibana, Y Fu, G Bu, ... Journal of Biological Chemistry 290 (22), 14208-14217, 2015 | 71 | 2015 |
ApoE (Apolipoprotein E) in brain pericytes regulates endothelial function in an isoform-dependent manner by modulating basement membrane components Y Yamazaki, M Shinohara, A Yamazaki, Y Ren, YW Asmann, T Kanekiyo, ... Arteriosclerosis, thrombosis, and vascular biology 40 (1), 128-144, 2020 | 68 | 2020 |
Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus Y Yamazaki, T Takahashi, M Hiji, T Kurashige, Y Izumi, T Yamawaki, ... Neuroscience letters 477 (2), 86-90, 2010 | 66 | 2010 |
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1 M Tachibana, M Shinohara, Y Yamazaki, CC Liu, J Rogers, G Bu, ... Experimental neurology 277, 1-9, 2016 | 63 | 2016 |
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain T Aikawa, Y Ren, Y Yamazaki, M Tachibana, MR Johnson, CT Anderson, ... Proceedings of the National Academy of Sciences 116 (47), 23790-23796, 2019 | 61 | 2019 |
Vascular ApoE4 impairs behavior by modulating gliovascular function Y Yamazaki, CC Liu, A Yamazaki, F Shue, YA Martens, Y Chen, W Qiao, ... Neuron 109 (3), 438-447. e6, 2021 | 46 | 2021 |
Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders Y Yamazaki, T Matsubara, T Takahashi, T Kurashige, E Dohi, M Hiji, ... PLoS One 6 (11), e26996, 2011 | 45 | 2011 |