Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway Y Tanaka, MV Gavrielides, Y Mitsuuchi, T Fujii, MG Kazanietz Journal of Biological Chemistry 278 (36), 33753-33762, 2003 | 323 | 2003 |
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 N Pescador, D Villar, D Cifuentes, M Garcia-Rocha, A Ortiz-Barahona, ... PloS one 5 (3), e9644, 2010 | 302 | 2010 |
Involvement of protein kinase C δ (PKCδ) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells: lack of proteolytic cleavage of PKCδ T Fujii, ML Garcı́a-Bermejo, JL Bernabó, J Caamaño, M Ohba, T Kuroki, ... Journal of Biological Chemistry 275 (11), 7574-7582, 2000 | 250 | 2000 |
Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future A Buriani, ML Garcia-Bermejo, E Bosisio, Q Xu, H Li, X Dong, ... Journal of ethnopharmacology 140 (3), 535-544, 2012 | 209 | 2012 |
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells A Galán, ML Garcı́a-Bermejo, A Troyano, NE Vilaboa, E de Blas, ... Journal of Biological Chemistry 275 (15), 11418-11424, 2000 | 196 | 2000 |
Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival E Conde, L Alegre, I Blanco-Sanchez, D Saenz-Morales, E Aguado-Fraile, ... PloS one 7 (3), e33258, 2012 | 194 | 2012 |
The role of intracellular oxidation in death induction (apoptosis and necrosis) in human promonocytic cells treated with stress inducers (cadmium, heat, X-rays) A Galán, L García-Bermejo, A Troyano, NE Vilaboa, C Fernández, ... European journal of cell biology 80 (4), 312-320, 2001 | 190 | 2001 |
Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats M Úbeda, M Lario, L Muñoz, MJ Borrero, M Rodríguez-Serrano, ... Journal of hepatology 64 (5), 1049-1057, 2016 | 188 | 2016 |
A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease JL López-Sendón Moreno, J García Caldentey, P Trigo Cubillo, ... Journal of neurology 263, 1390-1400, 2016 | 147 | 2016 |
A pilot study identifying a set of microRNAs as precise diagnostic biomarkers of acute kidney injury E Aguado-Fraile, E Ramos, E Conde, M Rodriguez, L Martin-Gomez, ... PloS one 10 (6), e0127175, 2015 | 146 | 2015 |
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19) J Rodríguez-Baño, J Pachón, J Carratala, P Ryan, I Jarrín, M Yllescas, ... Clinical Microbiology and Infection 27 (2), 244-252, 2021 | 142 | 2021 |
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCα ML Garcia-Bermejo, FC Leskow, T Fujii, Q Wang, PM Blumberg, M Ohba, ... Journal of Biological Chemistry 277 (1), 645-655, 2002 | 137 | 2002 |
β2-Chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain MJ Caloca, ML Garcia-Bermejo, PM Blumberg, NE Lewin, E Kremmer, ... Proceedings of the National Academy of Sciences 96 (21), 11854-11859, 1999 | 131 | 1999 |
miR‐9‐5p suppresses pro‐fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX 4 and TGFBR 2 M Fierro‐Fernández, Ó Busnadiego, P Sandoval, C Espinosa‐Díez, ... EMBO reports 16 (10), 1358-1377, 2015 | 104 | 2015 |
Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis L Muñoz, MJ Borrero, M Úbeda, E Conde, R Del Campo, ... Hepatology 70 (3), 925-938, 2019 | 102 | 2019 |
Intracellular delivery of an antibody targeting Gasdermin-B reduces HER2 breast cancer aggressiveness. MBG Molina-Crespo A, Cadete A, Sarrio D, Gamez-Chiachio M, Martinez L, Chao ... Clin Cancer Res., 2019 | 99 | 2019 |
Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells S Valle, S Alcalá, L Martin-Hijano, P Cabezas-Sáinz, D Navarro, ... Nature Communications 11 (1), 5265, 2020 | 98 | 2020 |
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target E Aguado-Fraile, E Ramos, D Saenz-Morales, E Conde, ... Public Library of Science 7 (9), e44305, 2012 | 95 | 2012 |
Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties MG Kazanietz, MJ Caloca, P Eroles, T Fujii, ML Garcıa-Bermejo, M Reilly, ... Biochemical pharmacology 60 (10), 1417-1424, 2000 | 93 | 2000 |
Translational value of animal models of kidney failure A Ortiz, MD Sanchez-Nino, MC Izquierdo, C Martin-Cleary, ... European journal of pharmacology 759, 205-220, 2015 | 90 | 2015 |