| Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target SC Barber, RJ Mead, PJ Shaw Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1762 (11-12 …, 2006 | 595 | 2006 |
| Applications of machine learning to diagnosis and treatment of neurodegenerative diseases MA Myszczynska, PN Ojamies, AMB Lacoste, D Neil, A Saffari, R Mead, ... Nature reviews neurology 16 (8), 440-456, 2020 | 472 | 2020 |
| Guidelines for preclinical animal research in ALS/MND: A consensus meeting AC Ludolph, C Bendotti, E Blaugrund, A Chio, L Greensmith, JP Loeffler, ... Amyotrophic Lateral Sclerosis 11 (1-2), 38-45, 2010 | 335 | 2010 |
| Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy CF Valori, K Ning, M Wyles, RJ Mead, AJ Grierson, PJ Shaw, M Azzouz Science translational medicine 2 (35), 35ra42-35ra42, 2010 | 333 | 2010 |
| TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD MA White, E Kim, A Duffy, R Adalbert, BU Phillips, OM Peters, ... Nature neuroscience 21 (4), 552-563, 2018 | 248 | 2018 |
| The membrane attack complex of complement causes severe demyelination associated with acute axonal injury RJ Mead, SK Singhrao, JW Neal, H Lassmann, BP Morgan The Journal of Immunology 168 (1), 458-465, 2002 | 247 | 2002 |
| Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation RJ Mead, N Shan, HJ Reiser, F Marshall, PJ Shaw Nature Reviews Drug Discovery 22 (3), 185-212, 2023 | 184 | 2023 |
| Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS) RJ Mead, EJ Bennett, AJ Kennerley, P Sharp, C Sunyach, P Kasher, ... PloS one 6 (8), e23244, 2011 | 112 | 2011 |
| An in vitro screening cascade to identify neuroprotective antioxidants in ALS SC Barber, A Higginbottom, RJ Mead, S Barber, PJ Shaw Free Radical Biology and Medicine 46 (8), 1127-1138, 2009 | 108 | 2009 |
| Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis RJ Mead, JW Neal, MR Griffiths, C Linington, M Botto, H Lassmann, ... Laboratory investigation 84 (1), 21-28, 2004 | 101 | 2004 |
| Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen CA Wood-Allum, SC Barber, J Kirby, P Heath, H Holden, R Mead, ... Brain 129 (7), 1693-1709, 2006 | 79 | 2006 |
| Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss MA White, Z Lin, E Kim, CM Henstridge, E Pena Altamira, CK Hunt, ... Acta neuropathologica communications 7, 1-16, 2019 | 74 | 2019 |
| Mannose-binding lectin alleles in a prospectively recruited UK population. R Mead, D Jack The Lancet 349 (9066), 1669-1670, 1997 | 74 | 1997 |
| S [+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis RJ Mead, A Higginbottom, SP Allen, J Kirby, E Bennett, SC Barber, ... Free Radical Biology and Medicine 61, 438-452, 2013 | 71 | 2013 |
| Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis Y Ciervo, K Ning, X Jun, PJ Shaw, RJ Mead Molecular neurodegeneration 12, 1-22, 2017 | 67 | 2017 |
| Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46) R Mead, SJ Hinchliffe, BP Morgan Immunology 98 (1), 137-143, 1999 | 56 | 1999 |
| NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS J Jiménez-Villegas, L Ferraiuolo, RJ Mead, PJ Shaw, A Cuadrado, ... Free Radical Biology and Medicine 173, 125-141, 2021 | 26 | 2021 |
| Early Detection of Motor Dysfunction in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Using Home Cage Running Wheels EJ Bennett, RJ Mead, M Azzouz, PJ Shaw, AJ Grierson PLoS One 9 (9), e107918, 2014 | 26 | 2014 |
| Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS) JA Watkins, JJP Alix, PJ Shaw, RJ Mead Scientific reports 11 (1), 16659, 2021 | 25 | 2021 |
| In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy M Plesia, OA Stevens, GR Lloyd, CA Kendall, I Coldicott, AJ Kennerley, ... ACS Chemical Neuroscience 12 (10), 1768-1776, 2021 | 19 | 2021 |
Pamela J ShawProfessor of Neurology, University of SheffieldVerified email at sheffield.ac.uk