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Jeffrey M. Lotthammer
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Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network
A Meller, M Ward, J Borowsky, M Kshirsagar, JM Lotthammer, F Oviedo, ...
Nature Communications 14 (1), 1177, 2023
622023
Direct prediction of intrinsically disordered protein conformational properties from sequence
JM Lotthammer, GM Ginell, D Griffith, R Emenecker, AS Holehouse
Nat Methods 21, 465–476, 2024
502024
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
A Meller, JM Lotthammer, LG Smith, B Novak, LA Lee, CC Kuhn, ...
Elife 12, e83602, 2023
212023
Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles
LA Lee, SK Barrick, A Meller, J Walklate, JM Lotthammer, JW Tay, ...
Journal of Biological Chemistry 299 (1), 2023
132023
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels
APJ Giese, WH Weng, KS Kindt, HHV Chang, JS Montgomery, EM Ratzan, ...
eLife 12, 2023
72023
Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies
SJ Lehman, A Meller, SO Solieva, JM Lotthammer, L Greenberg, ...
bioRxiv, 2023
32023
In Silico Electrophysiology of Inner-Ear Mechanotransduction Channel TMC1 Models
S Walujkar, JM Lotthammer, CR Nisler, JC Sudar, A Ballesteros, ...
bioRxiv, 2021.09. 17.460860, 2021
32021
Direct prediction of intermolecular interactions driven by disordered regions
GM Ginell, RJ Emenecker, JM Lotthammer, ET Usher, AS Holehouse
bioRxiv, 2024.06. 03.597104, 2024
22024
Structuring Inner-ear Mechanotransduction
D Choudhary, Y Narui, B Neel, S Walujkar, JM Lotthammer, JC Sudar, ...
Biophysical Journal 118 (3), 13a, 2020
12020
High-throughput affinity measurements of direct interactions between activation domains and co-activators
N DelRosso, PH Suzuki, D Griffith, JM Lotthammer, B Novak, S Kocalar, ...
bioRxiv, 2024
2024
Rhythmidia: a modern tool for circadian period analysis of filamentous fungi
AT Keeley, JM Lotthammer, JF Pelham
PLOS Computational Biology 20 (8), e1012167, 2024
2024
An easy-to-use computational tool for predicting 3D properties of disordered proteins
JM Lotthammer, AS Holehouse
Nat Methods, 2024
2024
Protein surface chemistry encodes an adaptive resistance to desiccation
PS Romero-Perez, HM Moran, A Horani, A Truong, ...
bioRxiv, 2024.07. 28.604841, 2024
2024
Molecular mechanisms underlying CIB function in inner-ear mechanotransduction
WH Weng, J Montgomery, S Walujkar, JM Lotthammer, APJ Giese, ...
Biophysical Journal 121 (3), 494a, 2022
2022
Exploring the myosin active/auto-inhibited state equilibrium by Markov state modeling
JM Lotthammer, A Meller, MJ Greenberg, GR Bowman
Biophysical Journal 121 (3), 260a-261a, 2022
2022
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Articles 1–15