| High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs S Rottenberg, JE Jaspers, A Kersbergen, E van der Burg, AOH Nygren, ... Proceedings of the National Academy of Sciences 105 (44), 17079-17084, 2008 | 1129 | 2008 |
| Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis PWB Derksen, X Liu, F Saridin, H van der Gulden, J Zevenhoven, B Evers, ... Cancer cell 10 (5), 437-449, 2006 | 714 | 2006 |
| Illegitimate WNT signaling promotes proliferation of multiple myeloma cells PWB Derksen, E Tjin, HP Meijer, MD Klok, HD Mac Gillavry, ... Proceedings of the National Academy of Sciences 101 (16), 6122-6127, 2004 | 412 | 2004 |
| Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin B Evers, R Drost, E Schut, M de Bruin, E van der Burg, PWB Derksen, ... Clinical Cancer Research 14 (12), 3916-3925, 2008 | 401 | 2008 |
| Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids JML Roodhart, LGM Daenen, ECA Stigter, HJ Prins, J Gerrits, ... Cancer cell 20 (3), 370-383, 2011 | 377 | 2011 |
| Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma PWB Derksen, RMJ Keehnen, LM Evers, MHJ Van Oers, M Spaargaren, ... Blood, The Journal of the American Society of Hematology 99 (4), 1405-1410, 2002 | 346 | 2002 |
| NCAM‐induced focal adhesion assembly: a functional switch upon loss of E‐cadherin F Lehembre, M Yilmaz, A Wicki, T Schomber, K Strittmatter, D Ziegler, ... The EMBO journal 27 (19), 2603-2615, 2008 | 234 | 2008 |
| Loss of E-cadherin-dependent cell–cell adhesion and the development and progression of cancer HC Bruner, PWB Derksen Cold Spring Harbor perspectives in biology 10 (3), a029330, 2018 | 215 | 2018 |
| The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma PWB Derksen, DJJ De Gorter, HP Meijer, RJ Bende, M Van Dijk, ... Leukemia 17 (4), 764-774, 2003 | 212 | 2003 |
| Chemotherapy enhances metastasis formation via VEGFR-1–expressing endothelial cells LGM Daenen, JML Roodhart, M van Amersfoort, M Dehnad, W Roessingh, ... Cancer research 71 (22), 6976-6985, 2011 | 190 | 2011 |
| Re-evaluating the role of FOXOs in cancer M Hornsveld, TB Dansen, PW Derksen, BMT Burgering Seminars in cancer biology 50, 90-100, 2018 | 170 | 2018 |
| Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells FJH Hoogwater, MW Nijkamp, N Smakman, EJA Steller, BL Emmink, ... Gastroenterology 138 (7), 2357-2367, 2010 | 170 | 2010 |
| Intravital microscopy: new insights into metastasis of tumors E Beerling, L Ritsma, N Vrisekoop, PWB Derksen, J van Rheenen Journal of cell science 124 (3), 299-310, 2011 | 168 | 2011 |
| The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation R van der Voort, TEI Taher, PWB Derksen, M Spaargaren, R van der Neut, ... Academic Press 79, 39-90, 2000 | 163 | 2000 |
| Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice PWB Derksen, TM Braumuller, E van der Burg, M Hornsveld, E Mesman, ... Disease models & mechanisms 4 (3), 347-358, 2011 | 157 | 2011 |
| Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance RCJ Schackmann, M Van Amersfoort, JHI Haarhuis, EJ Vlug, VA Halim, ... The Journal of clinical investigation 121 (8), 3176-3188, 2011 | 144 | 2011 |
| p120-catenin in cancer–mechanisms, models and opportunities for intervention RCJ Schackmann, M Tenhagen, RAH van de Ven, PWB Derksen Journal of cell science 126 (16), 3515-3525, 2013 | 118 | 2013 |
| Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma EPM Tjin, RWJ Groen, I Vogelzang, PWB Derksen, MD Klok, HP Meijer, ... Blood 107 (2), 760-768, 2006 | 117 | 2006 |
| E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer I Bajrami, R Marlow, M van de Ven, R Brough, HN Pemberton, J Frankum, ... Cancer discovery 8 (4), 498-515, 2018 | 112 | 2018 |
| Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer EJ Vlug, RAH Van De Ven, JF Vermeulen, P Bult, PJ Van Diest, ... Cellular Oncology 36, 375-384, 2013 | 92 | 2013 |
Jos JonkersProfessor at Leiden University and group leader at Netherlands Cancer Institute, Oncode InstituteVerified email at nki.nl