Does the lipid bilayer orchestrate access and binding of ligands to transmembrane orthosteric/allosteric sites of GPCRs? CT Szlenk, J B GC, S Natesan Molecular Pharmacology, 2019 | 60 | 2019 |
Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response SM Pokharel, NK Shil, J B. GC, ZT Colburn, SY Tsai, JA Segovia, ... Nature Communications, 2019 | 60 | 2019 |
The Ebola virus protein VP40 hexamer enhances the clustering of PI (4, 5) P2 lipids in the plasma membrane JB GC, BS Gerstman, RV Stahelin, P Chapagain Physical Chemistry Chemical Physics, 2016 | 57 | 2016 |
A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine K Del Vecchio, CT Frick, JB GC, S Oda, BS Gerstman, EO Saphire, ... Journal of Biological Chemistry, jbc. M117. 816280, 2018 | 44 | 2018 |
Molecular Dynamics Investigations of the α-Helix to β-Barrel Conformational Transformation in the RfaH Transcription Factor J GC, YR Bhandari, BS Gerstman, PP Chapagain The Journal of Physical Chemistry B 118 (19), 5101-5108, 2014 | 44 | 2014 |
The Role of the Interdomain Interactions on RfaH Dynamics and Conformational Transformation JB GC, BS Gerstman, PP Chapagain The Journal of Physical Chemistry B 119 (40), 12750-12759, 2015 | 35 | 2015 |
Membrane association and localization dynamics of the Ebola virus matrix protein VP40 JB GC, BS Gerstman, PP Chapagain Biochimica et Biophysica Acta (BBA)-Biomembranes 1859 (10), 2012-2020, 2017 | 31 | 2017 |
Interdomain salt‐bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization JB GC, KA Johnson, ML Husby, CT Frick, BS Gerstman, RV Stahelin, ... Protein Science 25 (9), 1648-1658, 2016 | 24 | 2016 |
Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments JB GC, R Ppkhrel, N Bhattarai, KA Johnson, B Gerstman, R Stahelin, ... Biochemical and Biophysical Research Communications, 2017 | 20 | 2017 |
Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer N Bhattarai, J B. GC, BS Gerstman, RV Stahelin, PP Chapagain RSC adv., 2017 | 20 | 2017 |
Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Pro-Resolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles J B. GC, CT Szlenk, S Natesan Molecular Pharmaceutics, 2020 | 15 | 2020 |
Membrane-facilitated receptor access and binding mechanisms of long-acting β2-adrenergic receptor (β2-AR) agonists CT Szlenk, JB GC, S Natesan Molecular Pharmacology, 2021 | 11 | 2021 |
RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis J Shintaku, WM Pernice, W Eyaid, JB GC, ZP Brown, ... The Journal of Clinical Investigation, 2022 | 10 | 2022 |
Mechanisms of Herb-Drug Interactions Involving Cinnamon and Cytochrome P450 2A6: Focus on Time-dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde MJ Espiritu, J Chen, J Yadav, M Larkin, RD Pelletier, JM Chan, JB GC, ... Drug Metabolism and Disposition, 2020 | 10* | 2020 |
Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3 JB Gc, J Chen, SM Pokharel, I Mohanty, C Mariasoosai, P Obi, ... Scientific Reports, 2023 | 4 | 2023 |
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential MJ Stutzman, CSJ Kim, DJ Tester, SK Hamrick, SM Dotzler, JR Giudicessi, ... Stem Cell Reports 17 (9), 2023-2036, 2022 | 3 | 2022 |
Allosteric modulation of α1β3γ2 GABAA receptors by farnesol through the neurosteroid sites J GC, CT Szlenk, A Diyaolu, P Obi, H Wei, X Shi, KM Gibson, S Natesan, ... Biophysical Journal, 2023 | 2 | 2023 |
Potential disruption of Ebola virus matrix by graphene nano-sheets R Pokhrel, GC Jeevan, N Bhattarai, P Chapagain, B Gerstman Biophysical Journal 114 (3), 218a, 2018 | 2 | 2018 |
Membrane-Facilitated Allosteric Modulation of GABAA Receptor by Farnesol: An In Silico Modeling and Simulation Study GC Jeevan, CT Szlenk, KM Gibson, SN Jean-Baptiste Roullet The Faseb Journal, 2019 | 1 | 2019 |
Application of Generative Artificial Intelligence in Predicting Membrane Partitioning of Drugs: Combining Denoising Diffusion Probabilistic Models and MD Simulations Reduces … P Obi, JB Gc, C Mariasoosai, A Diyaolu, S Natesan Journal of Chemical Theory and Computation 20 (14), 5866-5881, 2024 | | 2024 |