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James Smyth
James Smyth
Associate Professor, Fralin Biomedical Research Institute, Department of Biological Sciences
Verified email at vtc.vt.edu
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Cited by
Year
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
D Horiuchi, L Kusdra, NE Huskey, S Chandriani, ME Lenburg, ...
Journal of Experimental Medicine 209 (4), 679-696, 2012
3892012
TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion
S Lamouille, E Connolly, JW Smyth, RJ Akhurst, R Derynck
Journal of cell science 125 (5), 1259-1273, 2012
3822012
Stromal cell–derived factor-1α is cardioprotective after myocardial infarction
A Saxena, JE Fish, MD White, S Yu, JWP Smyth, RM Shaw, JM DiMaio, ...
Circulation 117 (17), 2224-2231, 2008
3012008
Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
JW Smyth, TT Hong, D Gao, JM Vogan, BC Jensen, TS Fong, ...
The Journal of clinical investigation 120 (1), 266-279, 2010
2642010
BIN1 localizes the L-type calcium channel to cardiac T-tubules
TT Hong, JW Smyth, D Gao, KY Chu, JM Vogan, TS Fong, BC Jensen, ...
PLoS biology 8 (2), e1000312, 2010
2632010
BIN1 is reduced and Cav1. 2 trafficking is impaired in human failing cardiomyocytes
TT Hong, JW Smyth, KY Chu, JM Vogan, TS Fong, BC Jensen, K Fang, ...
Heart rhythm 9 (5), 812-820, 2012
1642012
Autoregulation of connexin43 gap junction formation by internally translated isoforms
JW Smyth, RM Shaw
Cell reports 5 (3), 611-618, 2013
1622013
Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane
JW Smyth, JM Vogan, PJ Buch, SS Zhang, TS Fong, TT Hong, RM Shaw
Circulation research 110 (7), 978-989, 2012
1392012
Iroquois homeobox gene 3 establishes fast conduction in the cardiac His–Purkinje network
SS Zhang, KH Kim, A Rosen, JW Smyth, R Sakuma, P Delgado-Olguín, ...
Proceedings of the National Academy of Sciences 108 (33), 13576-13581, 2011
1372011
The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation
R Veeraraghavan, GS Hoeker, A Alvarez-Laviada, D Hoagland, X Wan, ...
Elife 7, e37610, 2018
1102018
A 14‐3‐3 mode‐1 binding motif initiates gap junction internalization during acute cardiac ischemia
JW Smyth, SS Zhang, JM Sanchez, S Lamouille, JM Vogan, GG Hesketh, ...
Traffic 15 (6), 684-699, 2014
962014
The pericyte microenvironment during vascular development
LB Payne, H Zhao, CC James, J Darden, D McGuire, S Taylor, JW Smyth, ...
Microcirculation 26 (8), e12554, 2019
642019
The gap junction life cycle
JW Smyth, RM Shaw
Heart Rhythm 9 (1), 151-153, 2012
502012
Altered translation initiation of Gja1 limits gap junction formation during epithelial–mesenchymal transition
CC James, MJ Zeitz, PJ Calhoun, S Lamouille, JW Smyth
Molecular biology of the cell 29 (7), 797-808, 2018
472018
Treatment of rapidly growing K-BALB and CT26 mouse tumours using Semliki Forest virus and its derived vector
JWP Smyth, MN Fleeton, BJ Sheahan, GJ Atkins
Gene Therapy 12 (2), 147-159, 2005
452005
Development of PLGA nanoparticles for sustained release of a connexin43 mimetic peptide to target glioblastoma cells
R Roberts, JW Smyth, J Will, P Roberts, CL Grek, GS Ghatnekar, Z Sheng, ...
Materials Science and Engineering: C 108, 110191, 2020
432020
Progression-mediated changes in mitochondrial morphology promotes adaptation to hypoxic peritoneal conditions in serous ovarian cancer
JP Grieco, ME Allen, JB Perry, Y Wang, Y Song, A Rohani, SLE Compton, ...
Frontiers in oncology 10, 600113, 2021
422021
Alternative mechanisms of translation initiation: An emerging dynamic regulator of the proteome in health and disease
CC James, JW Smyth
Life sciences 212, 138-144, 2018
412018
Extracellular sodium dependence of the conduction velocity-calcium relationship: evidence of ephaptic self-attenuation
S George, M Bonakdar, M Zeitz, R Davalos, J Smyth, S Poelzing
Biophysical Journal 110 (3), 30a-31a, 2016
412016
Forward trafficking of ion channels: what the clinician needs to know
JW Smyth, RM Shaw
Heart rhythm 7 (8), 1135-1140, 2010
402010
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