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Celia A Schiffer
Celia A Schiffer
Professor and Chair of Biochemistry and Molecular Biotechnology, U Mass Chan Medical School
Dirección de correo verificada de umassmed.edu - Página principal
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Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
M Prabu-Jeyabalan, E Nalivaika, CA Schiffer
Structure 10 (3), 369-381, 2002
4312002
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor
DLNG Surleraux, A Tahri, WG Verschueren, GME Pille, HA De Kock, ...
Journal of medicinal chemistry 48 (6), 1813-1822, 2005
3192005
Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
NM King, M Prabu-Jeyabalan, EA Nalivaika, P Wigerinck, MP de Béthune, ...
Journal of virology 78 (21), 12012-12021, 2004
3092004
Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments
TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ...
Journal of virology 77 (8), 4836-4847, 2003
2912003
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
F Muecksch, Y Weisblum, CO Barnes, F Schmidt, D Schaefer-Babajew, ...
Immunity 54 (8), 1853-1868. e7, 2021
2592021
Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance
WRP Scott, CA Schiffer
Structure 8 (12), 1259-1265, 2000
2592000
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ...
PLoS pathogens 8 (7), e1002832, 2012
2512012
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
KP Romano, A Ali, WE Royer, CA Schiffer
Proceedings of the National Academy of Sciences 107 (49), 20986-20991, 2010
2202010
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
M Prabu-Jeyabalan, E Nalivaika, CA Schiffer
Journal of molecular biology 301 (5), 1207-1220, 2000
2182000
TEMP: a computational method for analyzing transposable element polymorphism in populations
J Zhuang, J Wang, W Theurkauf, Z Weng
Nucleic acids research 42 (11), 6826-6838, 2014
198*2014
Combating susceptibility to drug resistance: lessons from HIV-1 protease
NM King, M Prabu-Jeyabalan, EA Nalivaika, CA Schiffer
Chemistry & biology 11 (10), 1333-1338, 2004
1882004
Molecular basis for drug resistance in HIV-1 protease
A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ...
Viruses 2 (11), 2509, 2010
1782010
Viral protease inhibitors
J Anderson, C Schiffer, SK Lee, R Swanstrom
Antiviral strategies, 85-110, 2009
1752009
Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A
MA Carpenter, M Li, A Rathore, L Lackey, EK Law, AM Land, B Leonard, ...
Journal of Biological Chemistry 287 (41), 34801-34808, 2012
1612012
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
M Ejemel, Q Li, S Hou, ZA Schiller, JA Tree, A Wallace, A Amcheslavsky, ...
Nature communications 11 (1), 4198, 2020
1602020
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces
SMD Shandilya, MNL Nalam, EA Nalivaika, PJ Gross, JC Valesano, ...
Structure 18 (1), 28-38, 2010
1542010
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
T Kouno, TV Silvas, BJ Hilbert, SMD Shandilya, MF Bohn, BA Kelch, ...
Nature communications 8 (1), 15024, 2017
1532017
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site
CA Schiffer, IJ Clifton, VJ Davisson, DV Santi, RM Stroud
Biochemistry 34 (50), 16279-16287, 1995
1521995
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
SC Pettit, GJ Henderson, CA Schiffer, R Swanstrom
Journal of virology 76 (20), 10226-10233, 2002
1492002
PTEN enters the nucleus by diffusion
F Liu, S Wagner, RB Campbell, JA Nickerson, CA Schiffer, AH Ross
Journal of cellular biochemistry 96 (2), 221-234, 2005
1462005
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Artículos 1–20