Drugs that target dynamic microtubules: a new molecular perspective RA Stanton, KM Gernert, JH Nettles, R Aneja Medicinal research reviews 31 (3), 443-481, 2011 | 590 | 2011 |
The binding mode of epothilone A on α, ß-tubulin by electron crystallography JH Nettles, H Li, B Cornett, JM Krahn, JP Snyder, KH Downing Science 305 (5685), 866-869, 2004 | 533 | 2004 |
The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density JP Snyder, JH Nettles, B Cornett, KH Downing, E Nogales Proceedings of the National Academy of Sciences 98 (9), 5312-5316, 2001 | 515 | 2001 |
Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition DA Judd, JH Nettles, N Nevins, JP Snyder, DC Liotta, J Tang, J Ermolieff, ... Journal of the American Chemical Society 123 (5), 886-897, 2001 | 443 | 2001 |
Microtubule-interacting drugs for cancer treatment PM Checchi, JH Nettles, J Zhou, JP Snyder, HC Joshi Trends in pharmacological sciences 24 (7), 361-365, 2003 | 248 | 2003 |
Bridging chemical and biological space:“target fishing” using 2D and 3D molecular descriptors JH Nettles, JL Jenkins, A Bender, Z Deng, JW Davies, M Glick Journal of medicinal chemistry 49 (23), 6802-6810, 2006 | 227 | 2006 |
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules M Hari, F Loganzo, T Annable, X Tan, S Musto, DB Morilla, JH Nettles, ... Molecular cancer therapeutics 5 (2), 270-278, 2006 | 205 | 2006 |
Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and laplacian-modified naive bayesian … M Glick, JL Jenkins, JH Nettles, H Hitchings, JW Davies Journal of chemical information and modeling 46 (1), 193-200, 2006 | 140 | 2006 |
“Bayes affinity fingerprints” improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept? A Bender, JL Jenkins, M Glick, Z Deng, JH Nettles, JW Davies Journal of chemical information and modeling 46 (6), 2445-2456, 2006 | 132 | 2006 |
The oxetane ring in taxol M Wang, B Cornett, J Nettles, DC Liotta, JP Snyder The Journal of Organic Chemistry 65 (4), 1059-1068, 2000 | 130 | 2000 |
Massage therapy decreases cancer-related fatigue: Results from a randomized early phase trial RMH Kinkead B, Schettler PJ, Larson ER, Carroll D, Sharenko M, Nettles J ... Cancer 124 (3), 546-554, 2018 | 120 | 2018 |
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones S Ducki, G Mackenzie, B Greedy, S Armitage, JFD Chabert, E Bennett, ... Bioorganic & medicinal chemistry 17 (22), 7711-7722, 2009 | 112 | 2009 |
Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function K Schafer-Hales, J Iaconelli, JP Snyder, A Prussia, JH Nettles, ... Molecular cancer therapeutics 6 (4), 1317-1328, 2007 | 85 | 2007 |
Approaches to hepatitis C treatment and cure using NS5A inhibitors JJ Kohler, JH Nettles, F Amblard, SJ Hurwitz, L Bassit, RA Stanton, ... Infection and drug resistance, 41-56, 2014 | 83 | 2014 |
Understanding false positives in reporter gene assays: in silico chemogenomics approaches to prioritize cell-based HTS data TJ Crisman, CN Parker, JL Jenkins, J Scheiber, M Thoma, ZB Kang, ... Journal of chemical information and modeling 47 (4), 1319-1327, 2007 | 77 | 2007 |
Rational design of the microtubule-targeting anti–breast cancer drug EM015 R Aneja, M Lopus, J Zhou, SN Vangapandu, A Ghaleb, J Yao, JH Nettles, ... Cancer research 66 (7), 3782-3791, 2006 | 71 | 2006 |
Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition JH Nettles, RA Stanton, J Broyde, F Amblard, H Zhang, L Zhou, J Shi, ... American Chemical Society, 2014 | 57 | 2014 |
Substrates and Inhibitors of SAMHD1 JA Hollenbaugh, J Shelton, S Tao, S Amiralaei, P Liu, X Lu, RW Goetze, ... PloS one 12 (1), e0169052, 2017 | 54 | 2017 |
Flexible 3D pharmacophores as descriptors of dynamic biological space JH Nettles, JL Jenkins, C Williams, AM Clark, A Bender, Z Deng, ... Journal of Molecular Graphics and Modelling 26 (3), 622-633, 2007 | 52 | 2007 |
Massage therapy for psychiatric disorders MH Rapaport, PJ Schettler, ER Larson, D Carroll, M Sharenko, J Nettles, ... Focus 16 (1), 24-31, 2018 | 37 | 2018 |