Using information from historical high-throughput screens to predict active compounds S Riniker, Y Wang, JL Jenkins, GA Landrum Journal of chemical information and modeling 54 (7), 1880-1891, 2014 | 96 | 2014 |
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length S Liu, MB Ginzberg, N Patel, M Hild, B Leung, Z Li, YC Chen, N Chang, ... eLife 7, e26947, 2018 | 84 | 2018 |
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma NT Ross, F Lohmann, S Carbonneau, A Fazal, WA Weihofen, S Gleim, ... Nature Chemical Biology 16 (1), 50-59, 2020 | 70 | 2020 |
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries N Moret, NA Clark, M Hafner, Y Wang, E Lounkine, M Medvedovic, ... Cell chemical biology 26 (5), 765-777. e3, 2019 | 68 | 2019 |
Cheminformatics tools for analyzing and designing optimized Small-Molecule collections and libraries N Moret, NA Clark, M Hafner, Y Wang, E Lounkine, M Medvedovic, ... Cell chemical biology 26 (5), 765-777. e3, 2019 | 68 | 2019 |
Evidence-based and quantitative prioritization of tool compounds in phenotypic drug discovery Y Wang, A Cornett, FJ King, Y Mao, F Nigsch, CG Paris, G McAllister, ... Cell chemical biology 23 (7), 862-874, 2016 | 61 | 2016 |
Systematic chemogenetic library assembly SM Canham, Y Wang, A Cornett, DS Auld, DK Baeschlin, M Patoor, ... Cell chemical biology 27 (9), 1124-1129, 2020 | 45 | 2020 |
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK C Tan, MB Ginzberg, R Webster, S Iyengar, S Liu, D Papadopoli, ... Developmental Cell 56 (12), 1756-1769. e7, 2021 | 44 | 2021 |
Balancing the influence of molecular complexity on fingerprint similarity searching Y Wang, J Bajorath Journal of chemical information and modeling 48 (1), 75-84, 2008 | 33 | 2008 |
Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy JM Cruz, N Hupper, LS Wilson, JB Concannon, Y Wang, B Oberhauser, ... Journal of Biological Chemistry 293 (30), 11837-11849, 2018 | 32 | 2018 |
Apparent asymmetry in fingerprint similarity searching is a direct consequence of differences in bit densities and molecular size Y Wang, H Eckert, J Bajorath ChemMedChem 2 (7), 1037-1042, 2007 | 29 | 2007 |
Bit silencing in fingerprints enables the derivation of compound class-directed similarity metrics Y Wang, J Bajorath Journal of chemical information and modeling 48 (9), 1754-1759, 2008 | 27 | 2008 |
A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling PD Koch, HR Miller, G Yu, JA Tallarico, PK Sorger, Y Wang, Y Feng, ... ACS chemical biology 13 (4), 1066-1081, 2018 | 19 | 2018 |
Shannon entropy-based fingerprint similarity search strategy Y Wang, H Geppert, J Bajorath Journal of chemical information and modeling 49 (7), 1687-1691, 2009 | 19 | 2009 |
Development of a compound class-directed similarity coefficient that accounts for molecular complexity effects in fingerprint searching Y Wang, J Bajorath Journal of chemical information and modeling 49 (6), 1369-1376, 2009 | 19 | 2009 |
Advanced fingerprint methods for similarity searching: balancing molecular complexity effects Y Wang, J Bajorath Combinatorial chemistry & high throughput screening 13 (3), 220-228, 2010 | 18 | 2010 |
Random reduction in fingerprint bit density improves compound recall in search calculations using complex reference molecules Y Wang, H Geppert, J Bajorath Chemical biology & drug design 71 (6), 511-517, 2008 | 14 | 2008 |
Activation of human STING by a molecular glue-like compound J Li, SM Canham, H Wu, M Henault, L Chen, G Liu, Y Chen, G Yu, ... Nature chemical biology, 1-8, 2023 | 9 | 2023 |
Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action AC Wang, HT Pham, JM Lipps, SM Brittain, E Harrington, Y Wang, FJ King, ... ACS chemical biology 14 (1), 20-26, 2018 | 9 | 2018 |
Quantitative prioritization of tool compounds for phenotypic screening Y Wang, JL Jenkins Phenotypic Screening: Methods and Protocols, 195-206, 2018 | 4 | 2018 |