Brad Sleebs

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Jonathan BaellExecutive Director Early Leads Chemistry, Lyterian TherapeuticsDirección de correo verificada de lyterian.com
Em. Prof. Brian J SmithLa Trobe Institute for Molecular ScienceDirección de correo verificada de latrobe.edu.au
Alan F. CowmanThe Walter and Eliza Hall Institute of Medical ResearchDirección de correo verificada de wehi.edu.au
Guillaume LesseneThe Walter and Eliza Hall Institute of Medical ResearchDirección de correo verificada de wehi.edu.au
Keith WatsonWalter & Eliza Hall Institute of Medical ReseachDirección de correo verificada de wehi.edu.au
peter m colmanDirección de correo verificada de wehi.edu.au
Peter CzabotarThe Walter & Eliza Hall Institute of Medical ResearchDirección de correo verificada de wehi.edu.au
John A FlygareMerckDirección de correo verificada de merck.com
Ian StreetWalter and Eliza Hall InstituteDirección de correo verificada de wehi.edu.au
Wayne FairbrotherGenentechDirección de correo verificada de gene.com
Justin BoddeyAssociate Professor, The Walter and Eliza Hall InstituteDirección de correo verificada de wehi.edu.au
Paul GilsonBurnet InstituteDirección de correo verificada de burnet.edu.au
Anthony HodderSenior Research Scientist Walter and Eliza Hall Institute of Medical ResDirección de correo verificada de wehi.edu.au
Brendan CrabbCEO and Director, Burnet InsituteDirección de correo verificada de burnet.edu.au
Danny WilsonUniversity of Adelaide, Research Centre for Infectious DiseasesDirección de correo verificada de adelaide.edu.au
Robin GasserThe University of MelbourneDirección de correo verificada de unimelb.edu.au
David CS HuangThe Walter and Eliza Hall Institute of Medical ResearchDirección de correo verificada de wehi.edu.au
Vicky AveryDistinguished Professor, Griffith UniversityDirección de correo verificada de griffith.edu.au
Douglas FairlieOlivia Newton-John Cancer Research Institute and La Trobe UniversityDirección de correo verificada de onjcri.org.au
Aya C TakiThe University of MelbourneDirección de correo verificada de unimelb.edu.au

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Brad Sleebs

Walter and Eliza Hall Institute

Dirección de correo verificada de wehi.edu.au - Página principal

Medicinal Chemistry Organic Chemistry Infectious Diseases Malaria


Título Ordenar por citas Ordenar por año Ordenar por título	Citado por Citado por	Año
Structure-guided design of a selective BCL-XL inhibitor G Lessene, PE Czabotar, BE Sleebs, K Zobel, KN Lowes, JM Adams, ... Nature chemical biology 9 (6), 390-397, 2013	435	2013
Discovery of a Potent and Selective BCL-X_L Inhibitor with in Vivo Activity ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ... ACS medicinal chemistry letters 5 (10), 1088-1093, 2014	319	2014
Mitoxantrone, More than Just Another Topoisomerase II Poison BJ Evison, BE Sleebs, KG Watson, DR Phillips, SM Cutts Medicinal Research Reviews 36 (2), 248-299, 2016	190	2016
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis W Wong, XC Bai, BE Sleebs, T Triglia, A Brown, JK Thompson, ... Nature microbiology 2 (6), 1-9, 2017	180	2017
Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome JA Boddey, TG Carvalho, AN Hodder, TJ Sargeant, BE Sleebs, ... Traffic 14 (5), 532-550, 2013	170	2013
Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites BE Sleebs, S Lopaticki, DS Marapana, MT O'Neill, P Rajasekaran, ... PLoS biology 12 (7), e1001897, 2014	153	2014
Screening the medicines for malaria venture pathogen box across multiple pathogens reclassifies starting points for open-source drug discovery S Duffy, ML Sykes, AJ Jones, TB Shelper, M Simpson, R Lang, ... Antimicrobial agents and chemotherapy 61 (9), 10.1128/aac. 00379-17, 2017	136	2017
Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle P Favuzza, M de Lera Ruiz, JK Thompson, T Triglia, A Ngo, RWJ Steel, ... Cell host & microbe 27 (4), 642-658. e12, 2020	119	2020
An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell MJ Coffey, BE Sleebs, AD Uboldi, A Garnham, M Franco, ND Marino, ... Elife 4, e10809, 2015	118	2015
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands EF Lee, PE Czabotar, H Yang, BE Sleebs, G Lessene, PM Colman, ... Journal of Biological Chemistry 284 (44), 30508-30517, 2009	116	2009
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes AN Hodder, BE Sleebs, PE Czabotar, M Gazdik, Y Xu, M T O'Neill, ... Nature Structural & Molecular Biology 22, 590-596, 2015	109	2015
Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X_L BE Sleebs, WJA Kersten, S Kulasegaram, G Nikolakopoulos, E Hatzis, ... Journal of Medicinal Chemistry 56 (13), 5514-5540, 2013	85	2013
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity BE Sleebs, PE Czabotar, WJ Fairbrother, WD Fairlie, JA Flygare, ... Journal of medicinal chemistry 54 (6), 1914-1926, 2011	84	2011
An appraisal of natural products active against parasitic nematodes of animals JF Garcia-Bustos, BE Sleebs, RB Gasser Parasites & Vectors 12, 1-22, 2019	81	2019
Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum DW Wilson, CD Goodman, BE Sleebs, GE Weiss, NWM de Jong, ... BMC biology 13 (52), 1, 2015	80	2015
The development process for discovery and clinical advancement of modern antimalarials TD Ashton, SM Devine, JJ Mohrle, B Laleu, JN Burrows, SA Charman, ... Journal of Medicinal Chemistry 62 (23), 10526-10562, 2019	75	2019
The facile production of N-methyl amino acids via oxazolidinones L Aurelio, RTC Brownlee, AB Hughes, BE Sleebs Australian Journal of Chemistry 53 (5), 425-433, 2000	71	2000
Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design JM 13. Brouwer, P Lan, AD Cowan, JP Bernardini, RW Birkinshaw, ... Cell Reports 68, 659-672, 2017	61	2017
Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax BE Sleebs, M Gazdik, MT O’Neill, P Rajasekaran, S Lopaticki, K Lackovic, ... Journal of medicinal chemistry 57 (18), 7644-7662, 2014	60	2014
Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity PR Gilson, C Tan, KE Jarman, KN Lowes, JM Curtis, W Nguyen, ... Journal of Medicinal Chemistry, 2017	57	2017

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