| Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4 T Takahashi, T Tagami, S Yamazaki, T Uede, J Shimizu, N Sakaguchi, ... The Journal of experimental medicine 192 (2), 303-310, 2000 | 2912 | 2000 |
| Caspase functions in cell death and disease DR McIlwain, T Berger, TW Mak Cold Spring Harbor perspectives in biology 5 (4), a008656, 2013 | 2627 | 2013 |
| TNF and ROS crosstalk in inflammation H Blaser, C Dostert, TW Mak, D Brenner Trends in cell biology 26 (4), 249-261, 2016 | 940 | 2016 |
| Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas Y Horie, A Suzuki, E Kataoka, T Sasaki, K Hamada, J Sasaki, K Mizuno, ... The Journal of clinical investigation 113 (12), 1774-1783, 2004 | 817 | 2004 |
| Conservation of the Notch signalling pathway in mammalian neurogenesis J Luis de la Pompa, A Wakeham, KM Correia, E Samper, S Brown, ... Development 124 (6), 1139-1148, 1997 | 809 | 1997 |
| Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum JL De la Pompa, LA Timmerman, H Takimoto, H Yoshida, AJ Elia, ... Nature 392 (6672), 182-186, 1998 | 793 | 1998 |
| Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK BJ Zarnegar, Y Wang, DJ Mahoney, PW Dempsey, HH Cheung, J He, ... Nature immunology 9 (12), 1371-1378, 2008 | 743 | 2008 |
| T cell-specific loss of Pten leads to defects in central and peripheral tolerance A Suzuki, MT Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, ... Immunity 14 (5), 523-534, 2001 | 714 | 2001 |
| DJ-1, a novel regulator of the tumor suppressor PTEN RH Kim, M Peters, YJ Jang, W Shi, M Pintilie, GC Fletcher, C DeLuca, ... Cancer cell 7 (3), 263-273, 2005 | 682 | 2005 |
| The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses WK Suh, BU Gajewska, H Okada, MA Gronski, EM Bertram, W Dawicki, ... Nature immunology 4 (9), 899-906, 2003 | 672 | 2003 |
| Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency W Schuler, IJ Weiler, A Schuler, RA Phillips, N Rosenberg, TW Mak, ... Cell 46 (7), 963-972, 1986 | 665 | 1986 |
| Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation DJ Mahoney, HH Cheung, RL Mrad, S Plenchette, C Simard, E Enwere, ... Proceedings of the National Academy of Sciences 105 (33), 11778-11783, 2008 | 658 | 2008 |
| CD8 is needed for development of cytotoxic T but not helper T cells WP Fung-Leung, MW Schilham, A Rahemtulla, TM Kündig, ... Cell 65 (3), 443-449, 1991 | 655 | 1991 |
| Requirement for Casper (c-FLIP) in regulation of death receptor–induced apoptosis and embryonic development WC Yeh, A Itie, AJ Elia, M Ng, HB Shu, A Wakeham, C Mirtsos, N Suzuki, ... Immunity 12 (6), 633-642, 2000 | 653 | 2000 |
| Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4 LEM Marengère, P Waterhouse, GS Duncan, HW Mittrücker, GS Feng, ... Science 272 (5265), 1170-1173, 1996 | 653 | 1996 |
| The role of cytokines in classical Hodgkin lymphoma BF Skinnider, TW Mak Blood, The Journal of the American Society of Hematology 99 (12), 4283-4297, 2002 | 647 | 2002 |
| The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo C Sirard, JL De La Pompa, A Elia, A Itie, C Mirtsos, A Cheung, S Hahn, ... Genes & development 12 (1), 107-119, 1998 | 642 | 1998 |
| Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice K Kishihara, J Penninger, VA Wallace, TM Kündig, K Kawal, A Wakeham, ... Cell 74 (1), 143-156, 1993 | 628 | 1993 |
| Positive and negative thymocyte selection induced by different concentrations of a single peptide E Sebzda, VA Wallace, J Mayer, RSM Yeung, TW Mak, PS Ohashi Science 263 (5153), 1615-1618, 1994 | 624 | 1994 |
| Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1 N Tanaka, M Ishihara, M Kitagawa, H Harada, T Kimura, T Matsuyama, ... Cell 77 (6), 829-839, 1994 | 621 | 1994 |
