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Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection Z Liu, S Chen, X Jin, Q Wang, K Yang, C Li, Q Xiao, P Hou, S Liu, S Wu, ... Cell & bioscience 7, 1-15, 2017 | 169 | 2017 |
A genome-wide CRISPR screen identifies genes critical for resistance to FLT3 inhibitor AC220 P Hou, C Wu, Y Wang, R Qi, D Bhavanasi, Z Zuo, C Dos Santos, S Chen, ... Cancer research 77 (16), 4402-4413, 2017 | 92 | 2017 |
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection P Hou, K Yang, P Jia, L Liu, Y Lin, Z Li, J Li, S Chen, S Guo, JA Pan, J Wu, ... Cell research 31 (1), 62-79, 2021 | 71 | 2021 |
Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection Q Wang, S Chen, Q Xiao, Z Liu, S Liu, P Hou, L Zhou, W Hou, W Ho, C Li, ... Retrovirology 14, 1-12, 2017 | 55 | 2017 |
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases P Hou, Y Lin, Z Li, R Lu, Y Wang, T Tian, P Jia, XI Zhang, L Cao, Z Zhou, ... Cellular & Molecular Immunology 18 (10), 2358-2371, 2021 | 32 | 2021 |
An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis P Hou, P Jia, K Yang, Z Li, T Tian, Y Lin, W Zeng, F Xing, Y Chen, C Li, ... Proceedings of the National Academy of Sciences 118 (3), e2015416118, 2021 | 22 | 2021 |
The ubiquitin E3 ligase parkin inhibits innate antiviral immunity through K48-linked polyubiquitination of RIG-I and MDA5 L Bu, H Wang, P Hou, S Guo, M He, J Xiao, P Li, Y Zhong, P Jia, Y Cao, ... Frontiers in immunology 11, 1926, 2020 | 22 | 2020 |
CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T-cell activation in refractory glioblastoma J Xiao, J Liang, J Fan, P Hou, X Li, H Zhang, K Li, L Bu, P Li, M He, ... Cancer Research 82 (18), 3359-3374, 2022 | 15 | 2022 |
VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability X Yu, S Chen, P Hou, M Wang, Y Chen, D Guo Biochemical and biophysical research communications 459 (2), 270-276, 2015 | 15 | 2015 |
CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3 Y Lin, Z Li, Y Wang, T Tian, P Jia, Y Ye, M He, Z Yang, C Li, D Guo, P Hou EMBO reports 23 (5), e54453, 2022 | 13 | 2022 |
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells J Wu, C Wu, F Xing, L Cao, W Zeng, L Guo, P Li, Y Zhong, H Jiang, M Luo, ... Cell Research 31 (9), 998-1010, 2021 | 12 | 2021 |
The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy P Hou, T Tian, P Jia, Y Lin, Z Li, Y Wang, Y Ye, C Li, D Guo Autophagy 19 (1), 365-366, 2023 | 10 | 2023 |
A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells J Wu, Y Zhong, X Liu, X Lu, W Zeng, C Wu, F Xing, L Cao, F Zheng, P Hou, ... Journal of Molecular Cell Biology 14 (2), mjac003, 2022 | 10 | 2022 |
Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma F Xing, J Xiao, J Wu, J Liang, X Lu, L Guo, P Li, P Hou, C Li, D Guo Signal transduction and targeted therapy 6 (1), 275, 2021 | 8 | 2021 |
Specific expression of interferon-γ induced by synergistic activation mediator-derived systems activates innate immunity and inhibits tumorigenesis S Liu, X Yu, Q Wang, Z Liu, Q Xiao, P Hou, Y Hu, W Hou, Z Yang, D Guo, ... Journal of microbiology and biotechnology 27 (10), 1855-1866, 2017 | 7 | 2017 |
CCDC50 promotes tumor growth through regulation of lysosome homeostasis P Jia, T Tian, Z Li, Y Wang, Y Lin, W Zeng, Y Ye, M He, X Ni, J Pan, ... EMBO reports 24 (10), e56948, 2023 | 3 | 2023 |
Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2 J Zhou, G Gao, P Hou, CM Li, D Guo Journal of cellular biochemistry 118 (11), 4020-4032, 2017 | 3 | 2017 |
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity Y Ye, P Jia, J Miao, Y Wang, Z Li, Y Lin, M He, S Liu, BR Zheng, J Wu, ... Autophagy, 2024 | | 2024 |
Reconstitution of RNA cap methylation reveals different features of SARS‐CoV‐2 and SARS‐CoV methyltransferases M He, L Cao, L Liu, X Jin, B Zheng, X Liu, J Zhuang, F Zhang, Z Yang, Y Ji, ... Journal of Medical Virology 96 (2), e29411, 2024 | | 2024 |