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George Yancopoulos
George Yancopoulos
Regeneron
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Vascular-specific growth factors and blood vessel formation
GD Yancopoulos, S Davis, NW Gale, JS Rudge, SJ Wiegand, J Holash
nature 407 (6801), 242-248, 2000
51702000
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
PC Maisonpierre, C Suri, PF Jones, S Bartunkova, SJ Wiegand, ...
Science 277 (5322), 55-60, 1997
47261997
Identification of ubiquitin ligases required for skeletal muscle atrophy
SC Bodine, E Latres, S Baumhueter, VKM Lai, L Nunez, BA Clarke, ...
Science 294 (5547), 1704-1708, 2001
40472001
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
C Suri, PF Jones, S Patan, S Bartunkova, PC Maisonpierre, S Davis, ...
Cell 87 (7), 1171-1180, 1996
36411996
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
SC Bodine, TN Stitt, M Gonzalez, WO Kline, GL Stover, R Bauerlein, ...
Nature cell biology 3 (11), 1014-1019, 2001
32112001
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
J Holash, PC Maisonpierre, D Compton, P Boland, CR Alexander, ...
Science 284 (5422), 1994-1998, 1999
29941999
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
JS Heier, DM Brown, V Chong, JF Korobelnik, PK Kaiser, QD Nguyen, ...
Ophthalmology 119 (12), 2537-2548, 2012
27032012
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
S Davis, TH Aldrich, PF Jones, A Acheson, DL Compton, V Jain, TE Ryan, ...
Cell 87 (7), 1161-1169, 1996
26161996
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
TG Boulton, SH Nye, DJ Robbins, NY Ip, E Radzlejewska, ...
Cell 65 (4), 663-675, 1991
25421991
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
TN Stitt, D Drujan, BA Clarke, F Panaro, Y Timofeyva, WO Kline, ...
Molecular cell 14 (3), 395-403, 2004
22572004
VEGF-Trap: a VEGF blocker with potent antitumor effects
J Holash, S Davis, N Papadopoulos, SD Croll, L Ho, M Russell, P Boland, ...
Proceedings of the National Academy of Sciences 99 (17), 11393-11398, 2002
21772002
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI (3) K/Akt/mTOR and PI (3) K/Akt/GSK3 pathways
C Rommel, SC Bodine, BA Clarke, R Rossman, L Nunez, TN Stitt, ...
Nature cell biology 3 (11), 1009-1013, 2001
19172001
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
C Hyman, M Hofer, YA Barde, M Juhasz, GD Yancopoulos, SP Squinto, ...
Nature 350 (6315), 230-232, 1991
19091991
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky, KF Chua, DB Lombard, WW Pang, MR Fischer, L Gellon, ...
Cell 124 (2), 315-329, 2006
18762006
Regulation of the germinal center response by microRNA-155
TH Thai, DP Calado, S Casola, KM Ansel, C Xiao, Y Xue, A Murphy, ...
Science 316 (5824), 604-608, 2007
18622007
Two phase 3 trials of dupilumab versus placebo in atopic dermatitis
EL Simpson, T Bieber, E Guttman-Yassky, LA Beck, A Blauvelt, MJ Cork, ...
New England Journal of Medicine 375 (24), 2335-2348, 2016
18522016
REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19
DM Weinreich, S Sivapalasingam, T Norton, S Ali, H Gao, R Bhore, ...
New England Journal of Medicine 384 (3), 238-251, 2021
17952021
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
G Thurston, C Suri, K Smith, J McClain, TN Sato, GD Yancopoulos, ...
Science 286 (5449), 2511-2514, 1999
17501999
Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma
M Castro, J Corren, ID Pavord, J Maspero, S Wenzel, KF Rabe, ...
New England journal of medicine 378 (26), 2486-2496, 2018
17212018
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
PC Maisonpierre, L Belluscio, S Squinto, NY Ip, ME Furth, RM Lindsay, ...
Science 247 (4949), 1446-1451, 1990
16991990
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