| Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models MV Lourenco, RL Frozza, GB de Freitas, H Zhang, GC Kincheski, ... Nature medicine 25 (1), 165-175, 2019 | 739 | 2019 |
| Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease ST Ferreira, JR Clarke, TR Bomfim, FG De Felice Alzheimer's & dementia 10 (1), S76-S83, 2014 | 428 | 2014 |
| TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s β-amyloid oligomers in mice and monkeys MV Lourenco, JR Clarke, RL Frozza, TR Bomfim, L Forny-Germano, ... Cell metabolism 18 (6), 831-843, 2013 | 406 | 2013 |
| Plastic modifications induced by object recognition memory processing JR Clarke, M Cammarota, A Gruart, I Izquierdo, JM Delgado-García Proceedings of the National Academy of Sciences 107 (6), 2652-2657, 2010 | 328 | 2010 |
| The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease AF Batista, L Forny‐Germano, JR Clarke, NM Lyra e Silva, J Brito‐Moreira, ... The Journal of pathology 245 (1), 85-100, 2018 | 210 | 2018 |
| Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation JR Clarke, NM Lyra e Silva, CP Figueiredo, RL Frozza, JH Ledo, ... EMBO molecular medicine 7 (2), 190-210, 2015 | 209 | 2015 |
| Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers CP Figueiredo, JR Clarke, JH Ledo, FC Ribeiro, CV Costa, HM Melo, ... Journal of Neuroscience 33 (23), 9626-9634, 2013 | 206 | 2013 |
| Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice JH Ledo, EP Azevedo, JR Clarke, FC Ribeiro, CP Figueiredo, D Foguel, ... Molecular psychiatry 18 (10), 1053-1054, 2013 | 166 | 2013 |
| Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease NM Lyra e Silva, RA Gonçalves, TA Pascoal, RAS Lima-Filho, ... Translational psychiatry 11 (1), 251, 2021 | 165 | 2021 |
| Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice CP Figueiredo, FGQ Barros-Aragão, RLS Neris, PS Frost, C Soares, ... Nature communications 10 (1), 3890, 2019 | 160 | 2019 |
| Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice GC Kincheski, IS Valentim, JR Clarke, D Cozachenco, ... Brain, behavior, and immunity 64, 140-151, 2017 | 109 | 2017 |
| Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory JR Clarke, JI Rossato, S Monteiro, LRM Bevilaqua, I Izquierdo, ... Neurobiology of learning and memory 90 (2), 374-381, 2008 | 108 | 2008 |
| Acute and chronic neurological consequences of early-life Zika virus infection in mice I Nem de Oliveira Souza, PS Frost, JV França, JB Nascimento-Viana, ... Science translational medicine 10 (444), eaar2749, 2018 | 103 | 2018 |
| Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α HM Melo, GSS da Silva, MR Sant’Ana, CVL Teixeira, JR Clarke, ... Cell Reports 30 (7), 2180-2194. e8, 2020 | 102 | 2020 |
| Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice J Brito-Moreira, MV Lourenco, MM Oliveira, FC Ribeiro, JH Ledo, LP Diniz, ... Journal of Biological Chemistry 292 (18), 7327-7337, 2017 | 91 | 2017 |
| Metabolic dysfunction in Alzheimer’s disease: from basic neurobiology to clinical approaches JR Clarke, FC Ribeiro, RL Frozza, FG De Felice, MV Lourenco Journal of Alzheimer's Disease 64 (s1), S405-S426, 2018 | 86 | 2018 |
| SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice FL Fontes-Dantas, GG Fernandes, EG Gutman, EV De Lima, LS Antonio, ... Cell reports 42 (3), 2023 | 75 | 2023 |
| Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson’s disease-like symptoms in mice JTS Fortuna, M Gralle, D Beckman, FS Neves, LP Diniz, PS Frost, ... Behavioural brain research 333, 150-160, 2017 | 44 | 2017 |
| Consequences of gestational diabetes to the brain and behavior of the offspring RALDE Sousa, YS Torres, CP Figueiredo, GF Passos, JR Clarke Anais da Academia Brasileira de Ciências 90 (2 suppl 1), 2279-2291, 2017 | 40 | 2017 |
| Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice PS Frost, F Barros-Aragão, RT da Silva, A Venancio, I Matias, ... Cell death & disease 10 (4), 323, 2019 | 36 | 2019 |
