Novel mutant-selective EGFR kinase inhibitors against EGFR T790M W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ... Nature 462 (7276), 1070-1074, 2009 | 1193 | 2009 |
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ... Nature 463 (7280), 501-506, 2010 | 694 | 2010 |
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ... Nature methods 16 (7), 595-602, 2019 | 580 | 2019 |
Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis J McLaurin, R Cecal, ME Kierstead, X Tian, AL Phinney, M Manea, ... Nature medicine 8 (11), 1263-1269, 2002 | 570 | 2002 |
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature communications 3 (1), 1288, 2012 | 302 | 2012 |
Force interacts with macromolecular structure in activation of TGF-β X Dong, B Zhao, RE Iacob, J Zhu, AC Koksal, C Lu, JR Engen, ... Nature 542 (7639), 55-59, 2017 | 265 | 2017 |
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications H Wei, J Mo, L Tao, RJ Russell, AA Tymiak, G Chen, RE Iacob, JR Engen Drug discovery today 19 (1), 95-102, 2014 | 233 | 2014 |
Applications of hydrogen/deuterium exchange MS from 2012 to 2014 GF Pirrone, RE Iacob, JR Engen Analytical chemistry 87 (1), 99-118, 2015 | 176 | 2015 |
Chemically induced degradation of the oncogenic transcription factor BCL6 N Kerres, S Steurer, S Schlager, G Bader, H Berger, M Caligiuri, C Dank, ... Cell reports 20 (12), 2860-2875, 2017 | 171 | 2017 |
Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7 I Lamberto, X Liu, HS Seo, NJ Schauer, RE Iacob, W Hu, D Das, ... Cell chemical biology 24 (12), 1490-1500. e11, 2017 | 168 | 2017 |
Tissue-Specific Oncogenic Activity of KRASA146T EJ Poulin, AK Bera, J Lu, YJ Lin, SD Strasser, JA Paulo, TQ Huang, ... Cancer discovery 9 (6), 738-755, 2019 | 150 | 2019 |
Structure and dynamic regulation of Abl kinases S Panjarian, RE Iacob, S Chen, JR Engen, TE Smithgall Journal of Biological Chemistry 288 (8), 5443-5450, 2013 | 146 | 2013 |
Hydrogen exchange mass spectrometry: are we out of the quicksand? RE Iacob, JR Engen Journal of the American Society for Mass Spectrometry 23 (6), 1003-1010, 2012 | 135 | 2012 |
Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements RE Iacob, GM Bou-Assaf, L Makowski, JR Engen, SA Berkowitz, D Houde Journal of Pharmaceutical Sciences 102 (12), 4315-4329, 2013 | 97 | 2013 |
Conformational disturbance in Abl kinase upon mutation and deregulation RE Iacob, T Pene-Dumitrescu, J Zhang, NS Gray, TE Smithgall, JR Engen Proceedings of the National Academy of Sciences 106 (5), 1386-1391, 2009 | 92 | 2009 |
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism NJ Schauer, X Liu, RS Magin, LM Doherty, WC Chan, SB Ficarro, W Hu, ... Scientific reports 10 (1), 5324, 2020 | 89 | 2020 |
Ion mobility adds an additional dimension to mass spectrometric analysis of solution‐phase hydrogen/deuterium exchange RE Iacob, JP Murphy III, JR Engen Rapid Communications in Mass Spectrometry 22 (18), 2898-2904, 2008 | 87 | 2008 |
Mass spectrometric characterization of glycosylation of hepatitis C virus E2 envelope glycoprotein reveals extended microheterogeneity of N-glycans RE Iacob, I Perdivara, M Przybylski, KB Tomer Journal of the American Society for Mass Spectrometry 19 (3), 428-444, 2011 | 81 | 2011 |
Mass spectrometric approaches for elucidation of antigen—antibody recognition structures in molecular immunology R Stefanescu, RE Iacob, EN Damoc, A Marquardt, E Amstalden, M Manea, ... European Journal of Mass Spectrometry 13 (1), 69-75, 2007 | 81 | 2007 |
Allosteric interactions between the myristate-and ATP-site of the Abl kinase RE Iacob, J Zhang, NS Gray, JR Engen PloS one 6 (1), e15929, 2011 | 78 | 2011 |