Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp KO Alfarouk, CM Stock, S Taylor, M Walsh, AK Muddathir, D Verduzco, ... Cancer cell international 15, 1-13, 2015 | 671 | 2015 |
Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question KO Alfarouk, D Verduzco, C Rauch, AK Muddathir, HHB Adil, ... Oncoscience 1 (12), 777, 2014 | 283 | 2014 |
Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH L Schwartz, T Seyfried, KO Alfarouk, JDV Moreira, S Fais Seminars in cancer biology 43, 134-138, 2017 | 130 | 2017 |
Tumor acidity as evolutionary spite KO Alfarouk, AK Muddathir, MEA Shayoub Cancers 3 (1), 408-414, 2011 | 126 | 2011 |
The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management KO Alfarouk, AHH Bashir, AN Aljarbou, ARM Ramadan, AK Muddathir, ... Frontiers in oncology 9, 75, 2019 | 103 | 2019 |
Tumor metabolism, cancer cell transporters, and microenvironmental resistance KO Alfarouk Journal of enzyme inhibition and medicinal chemistry 31 (6), 859-866, 2016 | 94 | 2016 |
The pentose phosphate pathway dynamics in cancer and its dependency on intracellular pH KO Alfarouk, SBM Ahmed, RL Elliott, A Benoit, SS Alqahtani, ME Ibrahim, ... Metabolites 10 (7), 285, 2020 | 87 | 2020 |
Evolution of tumor metabolism might reflect carcinogenesis as a reverse evolution process (dismantling of multicellularity) KO Alfarouk, MEA Shayoub, AK Muddathir, GO Elhassan, AHH Bashir Cancers 3 (3), 3002-3017, 2011 | 71 | 2011 |
Riparian ecosystems in human cancers KO Alfarouk, ME Ibrahim, RA Gatenby, JS Brown Evolutionary applications 6 (1), 46-53, 2013 | 67 | 2013 |
Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases S Harguindey, D Stanciu, J Devesa, K Alfarouk, RA Cardone, JDP Orozco, ... Seminars in cancer biology 43, 157-179, 2017 | 65 | 2017 |
Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta, MR Greco, ... Cancers 14 (10), 2486, 2022 | 58 | 2022 |
Tumor microenvironment features and chemoresistance in pancreatic ductal adenocarcinoma: Insights into targeting physicochemical barriers and metabolism as therapeutic approaches TMA Carvalho, D Di Molfetta, MR Greco, T Koltai, KO Alfarouk, ... Cancers 13 (23), 6135, 2021 | 46 | 2021 |
Vascular measurements correlate with estrogen receptor status MC Lloyd, KO Alfarouk, D Verduzco, MM Bui, RJ Gillies, ME Ibrahim, ... BMC cancer 14, 1-11, 2014 | 45 | 2014 |
The interplay of dysregulated pH and electrolyte imbalance in cancer KO Alfarouk, SBM Ahmed, A Ahmed, RL Elliott, ME Ibrahim, HS Ali, ... Cancers 12 (4), 898, 2020 | 44 | 2020 |
Of mitochondrion and COVID-19 KO Alfarouk, STS Alhoufie, A Hifny, L Schwartz, AS Alqahtani, ... Journal of enzyme inhibition and medicinal chemistry 36 (1), 1258-1266, 2021 | 35 | 2021 |
The role of sodium hydrogen exchanger 1 in dysregulation of proton dynamics and reprogramming of cancer metabolism as a sequela RA Cardone, KO Alfarouk, RL Elliott, SS Alqahtani, SBM Ahmed, ... International Journal of Molecular Sciences 20 (15), 3694, 2019 | 35 | 2019 |
Doxycycline as potential anti-cancer agent I Ali, KO Alfarouk, SJ Reshkin, ME Ibrahim Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2017 | 30 | 2017 |
Pathogenesis and Management of COVID-19 KO Alfarouk, STS AlHoufie, SBM Ahmed, M Shabana, A Ahmed, ... Journal of Xenobiotics 11 (2), 77-93, 2021 | 17 | 2021 |
Hydrogen ion dynamics of cancer and a new molecular, biochemical and metabolic approach to the etiopathogenesis and treatment of brain malignancies S Harguindey, J Polo Orozco, KO Alfarouk, J Devesa International journal of molecular sciences 20 (17), 4278, 2019 | 17 | 2019 |
Drug development: stages of drug development GO Elhassa, KO Alfarouk J Pharmacovigil 3 (03), 140-142, 2015 | 17 | 2015 |