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Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1 MC Maiuri, G Le Toumelin, A Criollo, JC Rain, F Gautier, P Juin, ... The EMBO journal 26 (10), 2527-2539, 2007 | 1381 | 2007 |
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Drug-target interactions: only the first step in the commitment to a programmed cell death? C Dive, JA Hickman British journal of cancer 64 (1), 192-196, 1991 | 590 | 1991 |
BH3-Only Proteins and BH3 Mimetics Induce Autophagy by Competitively Disrupting the Interaction between Beclin 1 and Bcl-2/Bcl-XL MC Maiuri, A Criollo, E Tasdemir, JM Vicencio, N Tajeddine, JA Hickman, ... Autophagy 3 (4), 374-376, 2007 | 551 | 2007 |
Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug … MFG Stevens, JA Hickman, SP Langdon, D Chubb, L Vickers, R Stone, ... Cancer research 47 (22), 5846-5852, 1987 | 548 | 1987 |
Limits to personalized cancer medicine IF Tannock, JA Hickman New England Journal of Medicine 375 (13), 1289-1294, 2016 | 450 | 2016 |
Three‐dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo JA Hickman, R Graeser, R de Hoogt, S Vidic, C Brito, M Gutekunst, ... Biotechnology journal 9 (9), 1115-1128, 2014 | 446 | 2014 |
Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia AJ Merritt, CS Potten, AJM Watson, DY Loh, K Nakayama, K Nakayama, ... Journal of cell science 108 (6), 2261-2271, 1995 | 390 | 1995 |
Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium S Pullan, J Wilson, A Metcalfe, GM Edwards, N Goberdhan, J Tilly, ... Journal of cell science 109 (3), 631-642, 1996 | 374 | 1996 |
Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax: Bcl-2 ratio CM Chresta, JRW Masters, JA Hickman Cancer research 56 (8), 1834-1841, 1996 | 366 | 1996 |
bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways TC Fisher, AE Milner, CD Gregory, AL Jackman, GW Aherne, JA Hartley, ... Cancer research 53 (14), 3321-3326, 1993 | 344 | 1993 |
Apoptosis and cancer chemotherapy G Makin, JA Hickman Cell and tissue research 301, 143-152, 2000 | 305 | 2000 |
Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation AJ Merritt, TD Allen, CS Potten, JA Hickman Oncogene 14 (23), 2759-2766, 1997 | 293 | 1997 |
Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl) imidazo [5, 1-d]-1, 2, 3, 5-tetrazin-4 (3H)-one, a novel broad-spectrum antitumor agent MFG Stevens, JA Hickman, R Stone, NW Gibson, GU Baig, E Lunt, ... Journal of medicinal chemistry 27 (2), 196-201, 1984 | 283 | 1984 |
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells B Marty, V Maire, E Gravier, G Rigaill, A Vincent-Salomon, M Kappler, ... Breast Cancer Research 10, 1-15, 2008 | 279 | 2008 |
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation DM Pritchard, AJM Watson, CS Potten, AL Jackman, JA Hickman Proceedings of the National Academy of Sciences 94 (5), 1795-1799, 1997 | 261 | 1997 |