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Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K ...
Scinece 370 (6515), eabd4585, 2020
2609*2020
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ...
Science 370 (6515), eabd4570, 2020
22432020
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
KR Engelhardt, S McGhee, S Winkler, A Sassi, C Woellner, ...
Journal of Allergy and Clinical Immunology 124 (6), 1289-1302. e4, 2009
5912009
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ...
Science immunology 6 (62), eabl4340, 2021
4952021
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19
T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ...
Science immunology 6 (62), eabl4348, 2021
3652021
DOCK8 deficiency: clinical and immunological phenotype and treatment options-a review of 136 patients
SE Aydin, SS Kilic, C Aytekin, A Kumar, O Porras, L Kainulainen, ...
Journal of clinical immunology 35, 189-198, 2015
3052015
Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized …
AO Eifan, T Akkoc, A Yildiz, S Keles, C Ozdemir, NN Bahceciler, IB Barlan
Clinical & Experimental Allergy 40 (6), 922-932, 2010
2862010
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA
LM Charbonnier, E Janssen, J Chou, TK Ohsumi, S Keles, JT Hsu, ...
Journal of Allergy and Clinical Immunology 135 (1), 217-227. e9, 2015
2772015
Human genetic and immunological determinants of critical COVID-19 pneumonia
Q Zhang, P Bastard, A Cobat, JL Casanova
Nature 603 (7902), 587-598, 2022
2602022
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
HH Jabara, DR McDonald, E Janssen, MJ Massaad, N Ramesh, ...
Nature immunology 13 (6), 612-620, 2012
2452012
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency
KR Engelhardt, ME Gertz, S Keles, AA Schäffer, EC Sigmund, C Glocker, ...
Journal of Allergy and Clinical Immunology 136 (2), 402-412, 2015
2032015
Inherited DOCK2 deficiency in patients with early-onset invasive infections
K Dobbs, C Domínguez Conde, SY Zhang, S Parolini, M Audry, J Chou, ...
New England Journal of Medicine 372 (25), 2409-2422, 2015
1932015
Anaphylaxis to multiple pollen allergen sublingual immunotherapy.
AO Eifan, S Keles, NN Bahceciler, IB Barlan
1912007
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
V Béziat, J Li, JX Lin, CS Ma, P Li, A Bousfiha, I Pellier, S Zoghi, S Baris, ...
Science immunology 3 (24), eaat4956, 2018
1762018
DOCK8 deficiency: insights into pathophysiology, clinical features and management
CM Biggs, S Keles, TA Chatila
Clinical Immunology 181, 75-82, 2017
1722017
Abatacept as a long-term targeted therapy for LRBA deficiency
A Kiykim, I Ogulur, E Dursun, LM Charbonnier, E Nain, S Cekic, ...
The Journal of Allergy and Clinical Immunology: In Practice 7 (8), 2790-2800 …, 2019
1512019
SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL ...
J Exp Med 218 (6), e20210446., 2021
1492021
A novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes
S Keles, E Karakoc-Aydiner, A Ozen, AG Izgi, A Tevetoglu, T Akkoc, ...
Journal of allergy and clinical immunology 128 (4), 808-815. e7, 2011
1492011
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
J Manry, P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, ...
Proceedings of the National Academy of Sciences 119 (21), 2022
1482022
Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score
VK Tesch, H Abolhassani, B Shadur, J Zobel, Y Mareika, S Sharapova, ...
Journal of Allergy and Clinical Immunology 145 (5), 1452-1463, 2020
1332020
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